Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Lipid droplets (LDs) are cellular organelles comprising a core of neutral lipids (glycerides,
sterols) encased within a single phospholipid membrane, responsible for storing surplus …

Pompe disease (PD) is a rare autosomal recessive disorder caused by mutations in the GAA
gene, localized on chromosome 17 and encoding for acid alpha-1, 4-glucosidase (GAA) …

Autophagy is an essential cellular process involving degradation of superfluous or defective
macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be …

Maintaining nutrient and energy homeostasis is crucial for the survival and function of cells
and organisms in response to environmental stress. Cells have evolved a stress-induced …

Brown adipocyte in brown adipose tissue (BAT) specializes in expending energy through
non-shivering thermogenesis, a process that produces heat either by uncoupling protein 1 …

Lysosomes are cellular organelles that function to catabolize both extra-and intracellular
cargo, act as a platform for nutrient sensing, and represent a core signaling node integrating …

Starch‐binding domain‐containing protein 1 (STBD1) is a glycogen‐binding protein
discovered in skeletal muscle gene differential expression that is pivotal to cellular energy …

A primary obstacle in translating genetic associations with disease into therapeutic
strategies is elucidating the cellular programs affected by genetic risk variants and effector …

Brown adipose tissue (BAT) is an important component of energy expenditure and
necessary to maintain body temperature for newborn mammals. In the previous study, we …