Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Metabolic dysfunction-associated fatty liver disease (commonly known as MAFLD) impacts
global health in epidemic proportions, and the resulting morbidity, mortality and economic …

Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac
tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis (PF) and …

Toxicology is moving away from animal testing towards in vitro tools to assess chemical
safety. This new testing framework requires a quantitative method, ie kinetic modelling …

Background: Considering the high toxicity and limited therapies available for treating
visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to …

Aims Amiodarone (AM) is a highly efficient drug for arrhythmias treatment, but its extra-
cardiac adverse effects offset its therapeutic efficacy. Nanoparticles (NPs)-based delivery …

Amiodarone was an orally effective antiarrhythmic drug widely used throughout the world,
had long-term administration side effects such as hepatotoxicity. The actions of two …

Background Metformin is the first prescribed drug for hyperglycemia in type 2 diabetes
mellitus. Mainly by activating AMPK pathway, this drug exerts various functions that among …

Drug-induced liver injury (DILI) is one of the leading causes of liver failure and withdrawal of
drugs from the market. A poor understanding of the precipitating event aetiology and …

胺碘酮是常用的广谱抗心律失常药物, 广泛用于治疗和预防多种心律失常性疾病.
长期口服胺碘酮可引起心动过缓, 甲状腺功能异常, 肺毒性, 血管异常, 胃肠道反应等副作用 …