m6A RNA methylation regulates the fate of endogenous retroviruses
T Chelmicki, E Roger, A Teissandier, M Dura… - Nature, 2021 - nature.com
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated
retroviral sequences that affect genome regulation and cell physiology throughout their RNA …
retroviral sequences that affect genome regulation and cell physiology throughout their RNA …
[HTML][HTML] MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
KRAS-LKB1 (KL) mutant lung cancers silence STING owing to intrinsic mitochondrial
dysfunction, resulting in T cell exclusion and resistance to programmed cell death (ligand) 1 …
dysfunction, resulting in T cell exclusion and resistance to programmed cell death (ligand) 1 …
The transcriptional and epigenetic landscape of cancer cell lineage plasticity
Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …
molecular and/or histologic identity, is a key driver of cancer progression and therapy …
IFNγ signaling integrity in colorectal cancer immunity and immunotherapy
The majority of colorectal cancer patients are not responsive to immune checkpoint
blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and …
blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and …
Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell
lung cancer (SCLC), yet the mechanisms driving benefit are poorly understood. To identify …
lung cancer (SCLC), yet the mechanisms driving benefit are poorly understood. To identify …
Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune
checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could …
checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could …
[HTML][HTML] Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
CM Gay, CA Stewart, EM Park, L Diao, SM Groves… - Cancer cell, 2021 - cell.com
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a
single entity with predictably poor results. Using tumor expression data and non-negative …
single entity with predictably poor results. Using tumor expression data and non-negative …
Endogenous retroviruses in the origins and treatment of cancer
N Jansz, GJ Faulkner - Genome biology, 2021 - Springer
Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …
[HTML][HTML] Targeting DNA methylation and EZH2 activity to overcome melanoma resistance to immunotherapy
Methylation of DNA at CpG sites is the most common and stable of epigenetic changes in
cancer. Hypermethylation acts to limit immune checkpoint blockade immunotherapy by …
cancer. Hypermethylation acts to limit immune checkpoint blockade immunotherapy by …
3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed,
several microdevices are being developed specifically for clinical use to test novel cancer …
several microdevices are being developed specifically for clinical use to test novel cancer …