Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease
H Ding, LX Li, PC Harris, J Yang, X Li - Nature communications, 2021 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of
PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal …
PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal …
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell of origin
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia,
which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified …
which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified …
Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in small cell lung cancer
T Murayama, J Nakayama, X Jiang, K Miyata… - Cancer Discovery, 2024 - AACR
Activating innate immunity in cancer cells through cytoplasmic nucleic acid sensing
pathways, a phenomenon known as “viral mimicry,” has emerged as an effective strategy to …
pathways, a phenomenon known as “viral mimicry,” has emerged as an effective strategy to …
Targeting lysine-specific demethylase 1 rescues major histocompatibility complex class I antigen presentation and overcomes programmed death-ligand 1 blockade …
Introduction SCLC is a highly aggressive neuroendocrine tumor that is characterized by
early acquired therapeutic resistance and modest benefit from immune checkpoint blockade …
early acquired therapeutic resistance and modest benefit from immune checkpoint blockade …
Nuclear membrane rupture and its consequences
J Maciejowski, EM Hatch - Annual review of cell and …, 2020 - annualreviews.org
The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …
nucleus and the cytosol. However, recent research has identified many conditions in …
Clonally expanded T cells reveal immunogenicity of rhabdoid tumors
Rhabdoid tumors (RTs) are genomically simple pediatric cancers driven by the biallelic
inactivation of SMARCB1, leading to SWI/SNF chromatin remodeler complex deficiency …
inactivation of SMARCB1, leading to SWI/SNF chromatin remodeler complex deficiency …
DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma
The development of more effective targeted therapies for hepatocellular carcinoma (HCC)
patients due to its aggressiveness is urgently needed. DNA methyltransferase inhibitors …
patients due to its aggressiveness is urgently needed. DNA methyltransferase inhibitors …
Cell cycle and beyond: exploiting new RB1 controlled mechanisms for cancer therapy
ES Knudsen, SC Pruitt, PA Hershberger, AK Witkiewicz… - Trends in cancer, 2019 - cell.com
Recent studies highlight the importance of the RB1 tumor suppressor as a target for cancer
therapy. Canonically, RB1 regulates cell cycle progression and represents the downstream …
therapy. Canonically, RB1 regulates cell cycle progression and represents the downstream …
Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence
Esophageal squamous cell carcinomas (ESCCs) harbor recurrent chromosome 3q
amplifications that target the transcription factor SOX2. Beyond its role as an oncogene in …
amplifications that target the transcription factor SOX2. Beyond its role as an oncogene in …
Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine
JR Conway, E Kofman, SS Mo, H Elmarakeby… - Genome medicine, 2018 - Springer
Immune checkpoint blockade (ICB) therapies, which potentiate the body's natural immune
response against tumor cells, have shown immense promise in the treatment of various …
response against tumor cells, have shown immense promise in the treatment of various …