Immune escape represents a major driver of acute myeloid leukemia (AML) reemergence
after allogeneic hematopoietic cell transplantation (allo-HCT), with up to 40% of relapses …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

SARS-CoV-2 promotes an imbalanced host response that underlies the development and
severity of COVID-19. Infections with viruses are known to modulate transposable elements …

The birth of RNAi technology has pioneered actionability at the molecular level. Compared
to DNA, RNA is less stable and therefore requires more demanding delivery vehicles. With …

Malignant kidney tumors account for 2% of the global cancer burden, and its incidence is on
the rise. In 2018, 63,000 new cases and 15,000 deaths due to kidney cancer will occur in the …

Small cell lung cancer (SCLC) is a pulmonary neuroendocrine cancer with very poor
prognosis and limited effective therapeutic options. Most patients are diagnosed at …

Mutations in subunits of the SWItch Sucrose Non-Fermentable (SWI/SNF) complex occur in
20% of all human tumors. Among these, the core subunit SMARCB1 is the most frequently …

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway
induces innate immunity by activating the production of inflammatory cytokines and type I …

It is now well accepted that the immune system can control cancer growth. However, tumors
escape immune-mediated control through multiple mechanisms and the downregulation or …

Objective This study exploits the intersection between molecular-targeted therapies and
immune-checkpoint inhibition to define new means to treat pancreatic cancer. Design …