The APOBEC family of cytidine deaminases has been proposed to represent a major
enzymatic source of mutations in cancer. Here, we summarize available evidence that links …

Epigenetic mechanisms such as histone modification play key roles in the pathogenesis of
multiple myeloma (MM). We previously showed that EZH2, a histone H3 lysine 27 (H3K27) …

Radiotherapy (RT) plus immunotherapy is a promising modality; however, the therapeutic
effects are insufficient, and the molecular mechanism requires clarification to further develop …

Dynamic small ubiquitin-like modifier (SUMO) linkages to diverse cellular protein groups are
critical to orchestrate resolution of stresses such as genome damage, hypoxia, or …

Human endogenous retroviruses (HERVs) represent∼ 8% of human genome, deriving from
exogenous retroviral infections of germ line cells occurred millions of years ago and being …

Prior data have variably implicated the inactivation of the mammalian SWItch/Sucrose Non-
Fermentable (mSWI/SNF) complex with increased tumor sensitivity to immune checkpoint …

The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …

Epigenetic regulators are a class of promising targets in combination with immune
checkpoint inhibitors for cancer treatment, but the impact of the broad effects of perturbing …

Intratumoral recruitment of immune cells following innate immune activation is critical for anti-
tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We …

The molecular mechanisms leading to resistance to PD-1 blockade are largely unknown.
Here, we characterize tumor biopsies from a patient with melanoma who displayed …