The interferon (IFN)-mediated innate immune response is the first line of defense against
viruses. However, an IFN-stimulated gene, the adenosine deaminase acting on RNA 1 …

Aberrant energy status contributes to multiple metabolic diseases, including obesity,
diabetes, and cancer, but the underlying mechanism remains elusive. Here, we report that …

Aberrant expression of viral-like repeat elements is a common feature of epithelial cancers,
and the substantial diversity of repeat species provides a distinct view of the cancer …

This review article addresses the largely unanticipated convergence of two landmark
discoveries. The first is the discovery of interferons, critical signaling molecules for all …

Immune checkpoint inhibitors (ICI) have significantly improved treatment outcomes for
several types of cancer over the past decade, but significant challenges that limit wider …

Dysregulated endogenous retroelements (EREs) are increasingly implicated in the initiation,
progression, and immune surveillance of human cancer. However, incomplete knowledge of …

Understanding tumor resistance to T cell immunotherapies is critical to improve patient
outcomes. Our study revealed a role for transcriptional suppression of the tumor-intrinsic …

RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …

Persistent infection with human papillomavirus (HPV) and immune surveillance failure may
be the initiating factors for the carcinogenesis of cervical squamous cell carcinoma (CSCC) …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal prognosis.
Currently, there is no effective therapy for PDAC, and a detailed molecular and functional …