Human Endogenous Retroviruses (HERVs) are accounting for 8% of the human genome.
These sequences are remnants from ancient germline infections by exogenous retroviruses …

Abstract TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a
broad spectrum of functions in cells. These range from innate immunity, inflammation and …

While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-
related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic …

Recently, we reported that expression of endogenous retroviruses (ERVs) is associated with
response to immune checkpoint blockade (ICB) in renal cell carcinoma (RCC). We show that …

Advances in immunotherapy, most notably antibodies targeting the inhibitory immune
receptors cytotoxic T-lymphocyte associated protein 4 (CTLA-4/CD152), programmed death …

In this work, we observed an increased presence of antibodies (Abs) against type I interferon
(IFN-I) in coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit …

Endogenous retroelements are DNA sequences which can duplicate and move to new
locations in the genome. Actively moving endogenous retroelements can be disruptive to the …

In recent years, there has been significant progress toward understanding the transcriptional
networks underlying mammalian immune responses, fueled by advances in regulatory …

Human endogenous retroviruses (HERVs) are widely believed to be remnants of ancestral
germ line infections by exogenous retroviruses. Although HERVs are deemed as …

Over the past several years, we have witnessed a resurgence of interest in the biology and
therapeutic vulnerabilities of small-cell lung cancer (SCLC). This has been driven in part …