We previously reported heightened expression of the human endogenous retroviral protein
HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating …

Interferons (IFNs) form a family of cytokines with pleiotropic effects that modulate the immune
response against multiple challenges like viral infections, autoimmune diseases, and …

Endothelial cells have multifaceted interactions with the immune system, both as initiators
and targets of immune responses. In vivo, apoptotic endothelial cells release two types of …

Type I interferon-mediated activation of immune cells can facilitate the generation of
productive tumor antigen-specific T cell responses in solid tumors. The cGAS/STING DNA …

Induction of nucleic acid sensing–mediated type I interferon (IFN) has emerged as a novel
approach to activate the immune system against cancer. Here we show that the depletion of …

Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer.
Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been …

Small cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but
a subset of SCLC has been termed “variant” due to the loss of NE characteristics. In this …

A hallmark of acute myeloid leukemia (AML) is epigenetic dysregulation, which is initiated by
recurrent translocations and/or mutations in transcription factors and chromatin regulators …

Endogenous retroviruses (ERVs), deriving from exogenous retroviral infections of germ line
cells occurred millions of years ago, represent~ 8% of human genome. Most ERVs are …

Renal cell carcinoma (RCC) comprises a group of malignancies arising from the kidney with
unique tumour-specific antigen (TSA) signatures that can trigger cytotoxic immunity. Two …