Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic
dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It …

Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or
more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic …

As the greatest defense organ of the body, the skin is exposed to endogenous and external
stressors that produce reactive oxygen species (ROS). When the antioxidant system of the …

Fatty liver disease constitutes a spectrum of liver diseases which begin with simple steatosis
and may progress to advance stages of steatohepatitis, cirrhosis, and hepatocellular …

In recent years, a great deal of attention has been paid to natural compounds due to their
many biological effects. Polyphenols are a class of plant derivatives that have been widely …

Epigenetics refers to the DNA chemistry changes that result in the modification of gene
transcription and translation independently of the underlying DNA coding sequence …

Scope Resveratrol is abundant in grapes. A protective role for resveratrol in anti-oxidation
and anti-inflammatory has been demonstrated. Rotenone is a pesticide, used to make …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of patients. Its
etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the …

Mitochondrial fission is a crucial process in maintaining metabolic homeostasis in normal
physiology and under conditions of stress. Its dysregulation has been associated with …

Resveratrol (RSV) is known to possess anticancer properties in many types of cancers like
breast cancer, in which POLD1 may serve as a potential target. However, the anticancer …