In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

Protein therapeutics carry inherent limitations of membrane impermeability and structural
instability, despite their predominant role in the modern pharmaceutical market. Effective …

Even 30 years after the discovery of magainins, biophysical and structural investigations on
how these peptides interact with membranes can still bear surprises and add new …

Antimicrobial peptides (AMPs), as a key component of the immune defense systems of
organisms, are a promising solution to the serious threat of drug-resistant bacteria to public …

Atomic force microscopy is an increasingly attractive tool to study how peptides disrupt
membranes. Often performed on reconstituted lipid bilayers, it provides access to time and …

Protein misfolding diseases (PMDs) are chronic and progressive, with no effective therapy
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …

Highlights•Factors determining AMP self-assembly discussed.•Effects of AMPs on amyloid
structures outlined.•AMP-based superstructures as functional biomaterials exemplified.•AMP …

Unsaturated and saturated phospholipids tend to laterally segregate, especially in the
presence of cholesterol. Small molecules such as neurotransmitters, toxins, drugs etc …

The membrane of Gram-negative bacteria (GNB) is especially robust due to the additional,
unique highly asymmetric outer membrane, with lipopolysaccharides (LPS) as the main …

Host‐defense peptides (HPDs) are bactericidal and immunomodulatory molecules, part of
the innate immune system of many organisms, including man. They kill bacteria mostly by …