[HTML][HTML] PSMA-targeting imaging and theranostic agents—Current status and future perspective
In the past two decades, extensive efforts have been made to develop agents targeting
prostate-specific membrane antigen (PSMA) for prostate cancer imaging and therapy. To …
prostate-specific membrane antigen (PSMA) for prostate cancer imaging and therapy. To …
[HTML][HTML] Good practices for 68Ga radiopharmaceutical production
Abstract Background The radiometal gallium-68 (68Ga) is increasingly used in diagnostic
positron emission tomography (PET), with 68Ga-labeled radiopharmaceuticals developed …
positron emission tomography (PET), with 68Ga-labeled radiopharmaceuticals developed …
[HTML][HTML] Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach
I Hrynchak, D Cocioabă, AI Fonseca, R Leonte… - Molecules, 2023 - mdpi.com
Antibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being
proposed as theranostic tools in multiple human diseases. While the production of copper …
proposed as theranostic tools in multiple human diseases. While the production of copper …
Synthesis of 68Ga-radiopharmaceuticals using both generator-derived and cyclotron-produced 68Ga as exemplified by [68Ga]Ga-PSMA-11 for prostate cancer PET …
ME Rodnick, C Sollert, D Stark, M Clark, A Katsifis… - Nature …, 2022 - nature.com
Abstract [68Ga] Ga-PSMA-11, a urea-based peptidomimetic, is a diagnostic
radiopharmaceutical for positron emission tomography (PET) imaging that targets the …
radiopharmaceutical for positron emission tomography (PET) imaging that targets the …
[HTML][HTML] Cyclotron Production of Gallium-68 Radiopharmaceuticals Using the 68Zn(p,n)68Ga Reaction and Their Regulatory Aspects
Designing and implementing various radionuclide production methods guarantees a
sustainable supply, which is important for medical use. The use of medical cyclotrons for …
sustainable supply, which is important for medical use. The use of medical cyclotrons for …
[HTML][HTML] A digital twin for 64Cu production with cyclotron and solid target system
One method for finding reliable and cost-effective solutions for designing radioisotope
production systems is represented by the “digital twin” philosophy of design. Looking at …
production systems is represented by the “digital twin” philosophy of design. Looking at …
Improved purification of cyclotron [68Ga] GaCl3 for the production of 68Ga radiopharmaceuticals
Abstract Introduction Increased demand for NetSpot and Illuccix as requirement to receive
the respective Lutathera and Pluvicto radiotherapies, and monitor subsequent response to …
the respective Lutathera and Pluvicto radiotherapies, and monitor subsequent response to …
Preparation of [68Ga] Ga-chloride from 68Zn solid target for the synthesis of pharmaceutical grade [68Ga] Ga-PSMA-11 and [68Ga] Ga-DOTA-TATE
S Chattopadhyay, S Ash, DG Mahesh, L Barua… - Applied Radiation and …, 2023 - Elsevier
Abstract 68 Ga is produced from enriched zinc-68 target electrodeposited on copper base
material which was irradiated with 15 MeV proton energy in 30 MeV cyclotron. A modified …
material which was irradiated with 15 MeV proton energy in 30 MeV cyclotron. A modified …
[HTML][HTML] Methods for the Determination of Transition Metal Impurities in Cyclotron-Produced Radiometals
V Forgács, A Fekete, B Gyuricza, D Szücs… - Pharmaceuticals, 2022 - mdpi.com
Cyclotron-produced radiometals must be separated from the irradiated target and purified
from other metal impurities, which could interfere with the radiolabeling process. We …
from other metal impurities, which could interfere with the radiolabeling process. We …
Production of Medical Radionuclides in the Center for Radiopharmaceutical Tumor Research—A Status Report
M Kreller, SA Brühlmann, T Knieß, K Kopka, M Walther - Instruments, 2024 - mdpi.com
A new Center for Radiopharmaceutical Cancer Research was established at the Helmholtz-
Zentrum Dresden-Rossendorf in 2017 to centralize radionuclide and radiopharmaceutical …
Zentrum Dresden-Rossendorf in 2017 to centralize radionuclide and radiopharmaceutical …