Cell death is a necessary event in life and is crucial for the regulation of organismal
development, homeostasis, aging and pathological conditions. There are different modes of …

Autophagy is a cellular process in which proteins and organelles are engulfed in
autophagosomal vesicles and transported to the lysosome/vacuole for degradation. Protein …

Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which
functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 …

Among the diverse protein binding modules, Sam (Sterile alpha motif) domains attract
attention due to their versatility. They are present in different organisms and play many …

One possible strategy for modulating autophagy is to disrupt the critical protein–protein
interactions (PPIs) formed during this process. Our attention is on the autophagy-related 12 …

Understanding drug selectivity mechanism is a long-standing issue for helping design drugs
with high specificity. Designing drugs targeting cyclin-dependent kinases (CDKs) with high …

Abstract Epidermal Growth Factor Receptor (EGFR) is a major drug target for non-small-cell
lung carcinoma (NSCLC). Tyrosine Kinase Inhibitors (TKIs) like erlotinib are potent inhibitors …

Background Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary
liver cancer cases and ranks as the second leading cause of cancer related death. Multiple …

Simple Summary Autophagy has long been regarded as playing both pro-and anti-
proliferative roles in many types of cancer, including PDAC. As the autophagy inhibitor CQ …

Autophagy is a lysosome-dependent bulk degradation process essential for cell viability but
excessive autophagy leads to a unique form of cell death termed autosis. Triple-negative …