Cyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed
in different cell types and tissues. cGMP targets a variety of downstream effector molecules …

The global malaria burden sometimes obscures that the genus Plasmodium comprises
diverse clades with lineages that independently gave origin to the extant human parasites …

Malaria is a life-threatening disease caused by parasites that are transmitted to humans
through the bites of infected mosquitoes. The early diagnosis and treatment of malaria are …

Background Cerebral malaria is a common presentation of severe Plasmodium falciparum
infection and remains an important cause of death in the tropics. Key aspects of its …

Neutrophils are the most abundant leukocytes in human peripheral blood. They form the first
line of defense against invading foreign pathogens and might play a crucial role in malaria …

Simple Summary Intercellular adhesion molecule 1 (ICAM-1) is a protein produced by cells
in blood vessel walls, as well as many other cell types. It localizes to the surface of these …

Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed …

Covering 1972 to 2021 Malaria remains a significant public health problem in some regions
of the world. The great efforts to control malaria have been severely compromised due to the …

Acute kidney injury (AKI) is a common feature of severe malaria, and an independent risk
factor for death. Previous research has suggested that an overactivation of the host …

The malaria-causing parasite, Plasmodium falciparum completely remodels its host red
blood cell (RBC) through the export of several hundred parasite proteins, including …