Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology

LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - ASPET
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

[HTML][HTML] Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

F Yang, Y Xiao, JH Ding, X Jin, D Ma, DQ Li, JX Shi… - Cell metabolism, 2023 - cell.com
Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

C Lennicke, HM Cochemé - Molecular Cell, 2021 - cell.com
Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

[HTML][HTML] Cellular Red-Ox system in health and disease: The latest update

AB Jena, RR Samal, NK Bhol, AK Duttaroy - Biomedicine & …, 2023 - Elsevier
Cells are continually exposed to reactive oxygen species (ROS) generated during cellular
metabolism. Apoptosis, necrosis, and autophagy are biological processes involving a …

Carbon quantum dots-based nanozyme from coffee induces cancer cell ferroptosis to activate antitumor immunity

L Yao, MM Zhao, QW Luo, YC Zhang, TT Liu, Z Yang… - ACS …, 2022 - ACS Publications
Carbon quantum dots (CQDs) offer huge potential due to their enzymatic properties as
compared to natural enzymes. Thus, discovery of CQDs-based nanozymes with low toxicity …

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Y Liu, Y Wan, Y Jiang, L Zhang, W Cheng - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Reactive oxygen species in macrophages: sources and targets

M Canton, R Sánchez-Rodríguez, I Spera… - Frontiers in …, 2021 - frontiersin.org
Reactive oxygen species (ROS) are fundamental for macrophages to eliminate invasive
microorganisms. However, as observed in nonphagocytic cells, ROS play essential roles in …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

NK cells and solid tumors: therapeutic potential and persisting obstacles

L Tong, C Jiménez-Cortegana, AHM Tay, S Wickström… - Molecular cancer, 2022 - Springer
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …