Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis are
complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Influenza virus is a significant pathogen in humans and animals with the ability to cause
extensive morbidity and mortality. Exuberant immune responses induced following infection …

The connection between inflammation and tumorigenesis is well-established and in the last
decade has received a great deal of supporting evidence from genetic, pharmacological …

Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel
disease. Proinflammatory cytokines have been suggested to regulate preneoplastic growth …

Bone resorption by osteoclasts and bone formation by osteoblasts are tightly coupled
processes implicating factors in TNF, bone morphogenetic protein, and Wnt families. In …

Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour …

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer 'hallmarks' through downstream activation of the Janus kinase/signal …

Cerebrovascular injury (CVI) is a common pathology caused by infections, injury, stroke,
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …