[HTML][HTML] The cellular functions and molecular mechanisms of G-quadruplex unwinding helicases in humans
Y Liu, X Zhu, K Wang, B Zhang, S Qiu - Frontiers in Molecular …, 2021 - frontiersin.org
G-quadruplexes (G4s) are stable non-canonical secondary structures formed by G-rich DNA
or RNA sequences. They play various regulatory roles in many biological processes. It is …
or RNA sequences. They play various regulatory roles in many biological processes. It is …
[HTML][HTML] Unravelling how single-stranded DNA binding protein coordinates DNA metabolism using single-molecule approaches
Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins
of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double …
of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double …
G-quadruplex recognition and remodeling by the FANCJ helicase
Guanine rich nucleic acid sequences can form G-quadruplex (G4) structures that interfere
with DNA replication, repair and RNA transcription. The human FANCJ helicase contributes …
with DNA replication, repair and RNA transcription. The human FANCJ helicase contributes …
[HTML][HTML] 5′ to 3′ unfolding directionality of DNA secondary structures by replication protein A: G-quadruplexes and duplexes
L Safa, NM Gueddouda, F Thiébaut… - Journal of Biological …, 2016 - ASBMB
The replication protein A (RPA) is a single-stranded DNA-binding protein that plays an
essential role in DNA metabolism. RPA is able to unfold G-quadruplex (G4) structures …
essential role in DNA metabolism. RPA is able to unfold G-quadruplex (G4) structures …
[HTML][HTML] Assembly of a G-Quadruplex Repair Complex by the FANCJ DNA Helicase and the REV1 Polymerase
The FANCJ helicase unfolds G-quadruplexes (G4s) in human cells to support DNA
replication. This action is coupled to the recruitment of REV1 polymerase to synthesize DNA …
replication. This action is coupled to the recruitment of REV1 polymerase to synthesize DNA …
Two steps forward, one step back: determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers
M Spies - DNA repair, 2014 - Elsevier
XPD-like helicases constitute a prominent DNA helicase family critical for many aspects of
genome maintenance. These enzymes share a unique structural feature, an auxiliary …
genome maintenance. These enzymes share a unique structural feature, an auxiliary …
[HTML][HTML] Residues in the RecQ C-terminal domain of the human Werner syndrome helicase are involved in unwinding G-quadruplex DNA
The structural and biophysical properties typically associated with G-quadruplex (G4)
structures render them a significant block for DNA replication, which must be overcome for …
structures render them a significant block for DNA replication, which must be overcome for …
Grip it and rip it: structural mechanisms of DNA helicase substrate binding and unwinding
B Bhattacharyya, JL Keck - Protein Science, 2014 - Wiley Online Library
Maintenance and faithful transmission of genomic information depends on the efficient
execution of numerous DNA replication, recombination, and repair pathways. Many of the …
execution of numerous DNA replication, recombination, and repair pathways. Many of the …
[HTML][HTML] Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase
Helicases play key roles in genome maintenance, yet it remains elusive how these enzymes
change conformations and how transitions between different conformational states regulate …
change conformations and how transitions between different conformational states regulate …
[HTML][HTML] Switch-like control of helicase processivity by single-stranded DNA binding protein
B Stekas, S Yeo, A Troitskaia, M Honda, S Sho… - Elife, 2021 - elifesciences.org
Helicases utilize nucleotide triphosphate (NTP) hydrolysis to translocate along single-
stranded nucleic acids (NA) and unwind the duplex. In the cell, helicases function in the …
stranded nucleic acids (NA) and unwind the duplex. In the cell, helicases function in the …