The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …
[HTML][HTML] Islet inflammation in type 2 diabetes and physiology
K Eguchi, R Nagai - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …
dysfunction has further highlighted the significance of inflammation in metabolic diseases …
[HTML][HTML] Islet inflammation in type 2 diabetes
M Böni-Schnetzler, DT Meier - Seminars in immunopathology, 2019 - Springer
Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …
[HTML][HTML] Regulation of tissue iron homeostasis: the macrophage “ferrostat”
Iron is an essential element for multiple fundamental biological processes required for life;
yet iron overload can be cytotoxic. Consequently, iron concentrations at the cellular and …
yet iron overload can be cytotoxic. Consequently, iron concentrations at the cellular and …
[PDF][PDF] α cell function and gene expression are compromised in type 1 diabetes
Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of
C-peptide long after disease onset but develop an inadequate glucagon response to …
C-peptide long after disease onset but develop an inadequate glucagon response to …
[HTML][HTML] Cystic fibrosis–related diabetes is caused by islet loss and inflammation
NJ Hart, R Aramandla, G Poffenberger, C Fayolle… - JCI insight, 2018 - ncbi.nlm.nih.gov
Cystic fibrosis–related (CF-related) diabetes (CFRD) is an increasingly common and
devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the …
devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the …
Cellular and molecular mechanisms coordinating pancreas development
The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …
systemic glucose metabolism and food digestion through the function of its endocrine and …
[PDF][PDF] Interrupted glucagon signaling reveals hepatic α cell axis and role for L-glutamine in α cell proliferation
ED Dean, M Li, N Prasad, SN Wisniewski… - Cell metabolism, 2017 - cell.com
Decreasing glucagon action lowers the blood glucose and may be useful therapeutically for
diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify …
diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify …
Signals in the pancreatic islet microenvironment influence β‐cell proliferation
KI Aamodt, AC Powers - Diabetes, Obesity and Metabolism, 2017 - Wiley Online Library
The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …
[HTML][HTML] Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
C Dai, Y Hang, A Shostak… - The Journal of …, 2017 - Am Soc Clin Investig
Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus.
Strategies to expand functional cells have focused on discovering and controlling …
Strategies to expand functional cells have focused on discovering and controlling …