Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

Iron is an essential element for multiple fundamental biological processes required for life;
yet iron overload can be cytotoxic. Consequently, iron concentrations at the cellular and …

Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of
C-peptide long after disease onset but develop an inadequate glucagon response to …

Cystic fibrosis–related (CF-related) diabetes (CFRD) is an increasingly common and
devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Decreasing glucagon action lowers the blood glucose and may be useful therapeutically for
diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus.
Strategies to expand functional cells have focused on discovering and controlling …