Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes
mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and progressive …

Type 1 diabetes is an insulin-dependent, autoimmune disease where the pancreatic β cells
are destroyed resulting in hyperglycemia. This multifactorial disease involves multiple …

Human islet research is providing new insights into human islet biology and diabetes, using
islets isolated at multiple US centers from donors with varying characteristics. This creates …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The classical view of type 1 diabetes assumes that the autoimmune mediated targeting of
insulin producing ß-cells is caused by an error of the immune system. Malfunction and stress …

The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized
insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging …

We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor
(Ab-4) to maintain glucose homeostasis in type 1 diabetic rodents. We noted durable and …

The increasing prevalence of the metabolic syndrome (MetS) is a threat to global public
health due to its lethal complications. Nonalcoholic fatty liver disease (NAFLD) is the hepatic …

Consumption of a high-energy Western diet triggers mild adaptive β cell proliferation to
compensate for peripheral insulin resistance; however, the underlying molecular …

The islets of Langerhans are highly organized structures that have species-specific, three-
dimensional tissue architecture. Islet architecture is critical for proper hormone secretion in …