Background The understanding of the regulation of glucagon secretion by pancreatic islet α-
cells remains elusive. We aimed to develop an in vitro model for investigating the function of …

The molecular mechanisms underlying obesity-induced increases in β cell mass and the
resulting β cell dysfunction need to be elucidated further. Our study revealed that GPR92 …

Microbial metabolites have a profound effect on the development of type 1 diabetes (T1D).
The cross-talk between the gut microbiota, the nervous system, and immune system is …

Pancreatic islets are clusters of hormone-secreting endocrine cells that rely on intricate cell-
cell communication mechanisms for proper function. The importance of multicellular …

In the pathogenesis of diabetes mellitus (DM), islet microvasculares are severely damaged
due to glucolipotoxicity and other reasons. Vascular endothelial growth factor (VEGF) is an …

β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

Introduction Mounting evidence suggest that macrophages play crucial roles in disease and
tissue regeneration. However, despite much efforts during the past decade, our knowledge …

Islet vascularization is essential for intact islet function and glucose homeostasis. We have
previously shown that primary cilia directly regulate insulin secretion. However, it remains …

There is a paucity of human models to study immune-mediated host damage. Here, we
utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID …

Altered islet architecture is associated with β cell dysfunction and type 2 diabetes (T2D)
progression, but molecular effectors of islet spatial organization remain mostly unknown …