Tissue tracking technologies such as speckle tracking echocardiography and feature
tracking cardiac magnetic resonance have enhanced the noninvasive assessment of …

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac
function in clinical and experimental research. Significant progress in the development of …

Despite the success of current therapies for acute myocardial infarction (MI), many patients
still develop adverse cardiac remodeling and heart failure. With the growing prevalence of …

Background Mouse models of heart disease are extensively employed. The
echocardiographic characterization of contractile function is usually focused on systolic …

Transverse aortic constriction (TAC) is a well-established model of pressure overload-
induced cardiac hypertrophy and failure in mice. The degree of constriction “tightness” …

Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF).
Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a …

Ultrasound imaging is a well-established clinical imaging technique providing real-time,
quantitative anatomical and physiological information in humans. The lack of ionizing …

Myocardial fibers are a 3-dimensional (3D) continuum that change orientation gradually
from a subendocradial righthanded helix to a subepicardial left-handed helix3 (Figure 3A …

Myocardial infarction (heart attack) is the number‐one killer of heart patients. Existing
treatments do not address cardiomyocyte (CM) loss and cannot regenerate the myocardium …

Background Branched‐chain amino acid (BCAA) catabolic defect is an emerging metabolic
hallmark in failing hearts in human and animal models. The therapeutic impact of targeting …