An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and
microRNAs. They can originate from both healthy and stressed cells, and provide a …

Ferroptosis is a recently discovered form of programmed cell death, but its regulatory
mechanisms remain poorly understood. Here, we show that the RNA-binding protein …

Background & Aims Autophagy plays a crucial role in hepatic homeostasis and its
deregulation has been associated with chronic liver disease. However, the effect of …

Background & Aims Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called
IRE1A) is a sensor of the unfolded protein response that is activated in the livers of patients …

Ferroptosis is a recently discovered form of programmed cell death, but its regulatory
mechanisms are not fully understood. In the current study, we reported that the BRD7-P53 …

Abstract Pinocembrin (5, 7-dihydroxyflavone) is a major flavonoid found in many plants,
fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies …

Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the
major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major …

Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Liver disease is responsible for approximately 1.2 million global deaths per year, which
account for 3.5% of all deaths worldwide.[1] Acute liver injury is often reversible, while …