Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …

Many small GTPases in the Ras and Rho families have a C-terminal polybasic region (PBR)
comprised of multiple lysines or arginines. The PBR controls diverse functions of these small …

Arf proteins are important regulators of cellular traffic and the founding members of an
expanding family of homologous proteins and genomic sequences. They depart from other …

Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, pleiotropic human disorder
characterized by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning …

Cellular cholesterol levels are tightly regulated and represent a balance of cholesterol
uptake, endogenous synthesis and efflux. Although the classic transcriptional regulations of …

Brain‐derived neurotrophic factor (BDNF) is a critical regulator of transcription‐dependent
adaptive neuronal responses, such as long‐term potentiation (LTP). Brief infusion of BDNF …

Mutations in the retinitis pigmentosa 2 (RP2) gene cause a severe form of X-linked retinal
degeneration. RP2 is a ubiquitous 350 amino acid plasma membrane-associated protein …

We recently demonstrated that expression of ADP-ribosylation factor (ARF)-like 4c (Arl4c)
induced by a combination of Wnt/β-catenin and epidermal growth factor/Ras signaling in …

Summary The small GTPase Arf6 regulates endocytosis, actin dynamics, and cell adhesion,
and one of its major activators is the exchange factor Arf nucleotide-binding site opener …

A cellular role and the mechanism of action for small GTPase Arl1 have been defined. Arl1-
GTP interacts with the GRIP domains of Golgin-97 and Golgin-245, a process dependent on …