Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

Most T lymphocytes, including regulatory T cells (Treg cells), differentiate in the thymus. The
age-dependent involution of this organ leads to decreasing production of T cells. Here we …

Historically the chemokine receptor CXCR4 and its canonical ligand CXCL12 are
associated with the bone marrow niche and hematopoiesis. However, CXCL12 exhibits …

Current approaches aiming to cure type 1 diabetes (T1D) have made a negligible number of
patients insulin-independent. In this review, we revisit the role of stem cell (SC)-based …

AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing
hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that attacks pancreatic β-cells,
leading to the destruction of insulitis-related islet β-cells. Islet β-cell transplantation has been …

The BM serves as a blood‐forming organ, but also supports the maintenance and immune
surveillance function of many T cells. Yet, in contrast to other organs, little is known about the …

The vascular endothelium is a critical determinant of diabetes-associated vascular
complications, and improving endothelial function is an important target for therapy …

BACKGROUND: This study reports the influence of CXCL12 and its receptor CXCR4 on the
progression of pancreatic cancer and illuminates the correlation between the …