[HTML][HTML] SARS-CoV-2 vaccines based on the spike glycoprotein and implications of new viral variants

D Martínez-Flores, J Zepeda-Cervantes… - Frontiers in …, 2021 - frontiersin.org
Coronavirus 19 Disease (COVID-19) originating in the province of Wuhan, China in 2019, is
caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), whose …

[HTML][HTML] Virus-like particles: Revolutionary platforms for developing vaccines against emerging infectious diseases

H Tariq, S Batool, S Asif, M Ali, BH Abbasi - Frontiers in microbiology, 2022 - frontiersin.org
Virus-like particles (VLPs) are nanostructures that possess diverse applications in
therapeutics, immunization, and diagnostics. With the recent advancements in biomedical …

The multifaceted biology of PCSK9

NG Seidah, A Prat - Endocrine reviews, 2022 - academic.oup.com
This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

SARS-CoV-2 RBD-tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

Y Valdes-Balbin, D Santana-Mederos… - ACS Chemical …, 2021 - ACS Publications
Controlling the global COVID-19 pandemic depends, among other measures, on developing
preventive vaccines at an unprecedented pace. Vaccines approved for use and those in …

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

R Peng, CK Wang, X Wang‐Kan, M Idorn, M Kjær… - EMBO …, 2022 - embopress.org
ZBP1 is an interferon‐induced cytosolic nucleic acid sensor that facilitates antiviral
responses via RIPK3. Although ZBP1‐mediated programmed cell death is widely described …

Molecular aspects concerning the use of the SARS-CoV-2 receptor binding domain as a target for preventive vaccines

Y Valdes-Balbin, D Santana-Mederos… - ACS central …, 2021 - ACS Publications
The development of recombinant COVID-19 vaccines has resulted from scientific progress
made at an unprecedented speed during 2020. The recombinant spike glycoprotein …

[HTML][HTML] Hemorrhagic fever with renal syndrome in Asia: history, pathogenesis, diagnosis, treatment, and prevention

A Sehgal, S Mehta, K Sahay, E Martynova, A Rizvanov… - Viruses, 2023 - mdpi.com
Hemorrhagic Fever with Renal Syndrome (HFRS) is the most frequently diagnosed zoonosis
in Asia. This zoonotic infection is the result of exposure to the virus-contaminated aerosols …

[HTML][HTML] Biological nanoparticles in vaccine development

SM Curley, D Putnam - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Vaccines represent one of the most successful public health initiatives worldwide. However,
despite the vast number of highly effective vaccines, some infectious diseases still do not …

[HTML][HTML] SARS-CoV-2 structural features may explain limited neutralizing-antibody responses

MF Bachmann, MO Mohsen, L Zha, M Vogel… - npj Vaccines, 2021 - nature.com
Neutralizing antibody responses of SARS-CoV-2-infected patients may be low and of short
duration. We propose here that coronaviruses employ a structural strategy to avoid strong …