[PDF][PDF] Riboflavin metabolism: role in mitochondrial function

S Balasubramaniam, J Yaplito-Lee - J. Transl. Genet. Genom, 2020 - f.oaes.cc
Riboflavin, known as vitamin B2, a water-soluble vitamin, is an essential nutrient in
vertebrates, hence adequate dietary intake is imperative. Riboflavin plays a role in a variety …

Maternal riboflavin deficiency, resulting in transient neonatal‐onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B

G Ho, A Yonezawa, S Masuda, K Inui, KG Sim… - Human …, 2011 - Wiley Online Library
Riboflavin, or vitamin B2, is a precursor to flavin adenine dinucleotide (FAD) and flavin
mononucleotide (FMN) molecules, required in biological oxidation‐reduction reactions. We …

Recent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas

HM Said - … Journal of Physiology-Gastrointestinal and Liver …, 2013 - journals.physiology.org
This review focuses on recent advances in our understanding of the mechanisms and
regulation of water-soluble vitamin (WSV) transport in the large intestine and pancreas, two …

Bioengineered riboflavin in nanotechnology

N Beztsinna, M Solé, N Taib, I Bestel - Biomaterials, 2016 - Elsevier
Riboflavin (RF) is an essential water-soluble vitamin with unique biological and
physicochemical properties such as transporterspecific cell internalization, implication in …

Emerging roles for riboflavin in functional rescue of mitochondrial β-oxidation flavoenzymes

BJ Henriques, RK Olsen, P Bross… - Current medicinal …, 2010 - ingentaconnect.com
Riboflavin, commonly known as vitamin B2, is the precursor of flavin cofactors. It is present in
our typical diet, and inside the cells it is metabolized to FMN and FAD. As a result of their …

[HTML][HTML] FAD synthesis and degradation in the nucleus create a local flavin cofactor pool

TA Giancaspero, G Busco, C Panebianco… - Journal of Biological …, 2013 - ASBMB
Background: FAD synthase is known to catalyze the biosynthesis of FAD in cytosol and
mitochondria. Results: The existence of a nuclear FAD synthase and a FAD-hydrolyzing …

[HTML][HTML] Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption …

S Yamamoto, K Inoue, T Murata, S Kamigaso… - Journal of biological …, 2010 - ASBMB
Nucleobases are important compounds that constitute nucleosides and nucleic acids.
Although it has long been suggested that specific transporters are involved in their intestinal …

[HTML][HTML] SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer

L Long, XX Pang, F Lei, JS Zhang, W Wang… - Cellular and Molecular …, 2018 - Springer
The human riboflavin transporter-3 (encoded by SLC52A3) plays a prominent role in
riboflavin absorption. Interestingly, abnormal expression patterns of SLC52A3 in multiple …

Biosynthesis of flavin cofactors in man: implications in health and disease

M Barile, T Anna Giancaspero, C Brizio… - Current …, 2013 - ingentaconnect.com
The primary role of the water-soluble vitamin B2, ie riboflavin, in cell biology is connected
with its conversion into FMN and FAD, the cofactors of a large number of dehydrogenases …

[HTML][HTML] Evaluation of riboflavin transporters as targets for drug delivery and theranostics

L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
The retention and cellular internalization of drug delivery systems and theranostics for
cancer therapy can be improved by targeting molecules. Since an increased uptake of …