[HTML][HTML] Evaluation of riboflavin transporters as targets for drug delivery and theranostics

L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
The retention and cellular internalization of drug delivery systems and theranostics for
cancer therapy can be improved by targeting molecules. Since an increased uptake of …

[HTML][HTML] Functional characteristics of the human ortholog of riboflavin transporter 2 and riboflavin-responsive expression of its rat ortholog in the small intestine indicate …

M Fujimura, S Yamamoto, T Murata, T Yasujima… - The Journal of …, 2010 - Elsevier
Riboflavin transporter (RFT) 2 has recently been identified as a transporter that may be,
mainly based on the functional characteristics of its rat ortholog (rRFT2), involved in the …

Early use of high‐dose riboflavin in a case of Brown–Vialetto–Van Laere syndrome

G Anand, N Hasan, S Jayapal, Z Huma… - … Medicine & Child …, 2012 - Wiley Online Library
Brown–Vialetto–Van Laere syndrome (BVVLS) is a genetic condition caused by a mutation
in the C20orf54 gene, which also codes for an intestinal riboflavin transporter. We report the …

Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegans

A Yerevanian, LM Murphy, S Emans, Y Zhou… - Aging …, 2022 - Wiley Online Library
Riboflavin is an essential cofactor in many enzymatic processes and in the production of
flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin …

RFT2 is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenesis by sustaining cell proliferation and protecting against cell death

XR Jiang, XY Yu, JH Fan, L Guo, C Zhu, W Jiang… - Cancer Letters, 2014 - Elsevier
Abstract Human riboflavin transporter 2 (RFT2, also termed as SLC52A3) was recently
identified as a susceptibility gene to esophageal squamous cell carcinoma (ESCC) …

[HTML][HTML] Differential expression of human riboflavin transporters-1,-2, and-3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake

VS Subramanian, SB Subramanya, L Rapp… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Transport of riboflavin (RF) across both the brush border membrane (BBM) and basolateral
membrane (BLM) of the polarized enterocyte occurs via specific carrier-mediated …

[HTML][HTML] In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts

J Jayapaul, S Arns, M Bunker, M Weiler, S Rutherford… - Nano Research, 2016 - Springer
Riboflavin (Rf) receptors bind and translocate Rf and its phosphorylated forms (eg flavin
mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways …

[HTML][HTML] Association of the plasma and tissue riboflavin levels with C20orf54 expression in cervical lesions and its relationship to HPV16 infection

A Aili, A Hasim, A Kelimu, X Guo, B Mamtimin… - PloS one, 2013 - journals.plos.org
Riboflavin deficiency can cause a variety of metabolic problems that lead to skin and
mucosal disorders. Limited evidence suggests that high intake of riboflavin may reduce …

The expression of riboflavin transporters in human colorectal cancer

V Tutino, ML Defrancesco, M Tolomeo… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Riboflavin transport in enterocytes is mediated by three translocators:
RFVT3 located on the apical membrane, and RFVT1 and RFVT2 on the basolateral …

[HTML][HTML] Development of novel experimental models to study flavoproteome alterations in human neuromuscular diseases: the effect of Rf therapy

M Tolomeo, A Nisco, P Leone, M Barile - International Journal of …, 2020 - mdpi.com
Inborn errors of Riboflavin (Rf) transport and metabolism have been recently related to
severe human neuromuscular disorders, as resulting in profound alteration of human …