Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …

Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …

Significance: Traumatic injury elicits a complex, dynamic, multidimensional inflammatory
response that is intertwined with complications such as multiple organ dysfunction and …

Background Complex biological processes such as acute inflammation induced by
trauma/hemorrhagic shock/(T/HS) are dynamic and multi-dimensional. We utilized …

Background Tools to predict death or spontaneous survival are necessary to inform liver
transplantation (LTx) decisions in pediatric acute liver failure (PALF), but such tools are not …

Inflammation is a complex, non-linear process central to many of the diseases that affect
both developed and emerging nations. A systems-based understanding of inflammation …

Objective: To gain insights into individual variations in acute inflammation and physiology.
Design: Large-animal study combined with mathematical modeling. Setting: Academic large …

Objectives: To familiarize clinicians with advances in computational disease modeling
applied to trauma and sepsis. Data Sources: PubMed search and review of relevant medical …

A central goal of industrialized nations is to provide personalized, pre-emptive and
predictive medicine, while maintaining healthcare costs at a minimum. To do so, we must …

Trauma, often accompanied by hemorrhage, is a leading cause of death worldwide, often
leading to inflammation-related late complications that include sepsis and multiple organ …