[HTML][HTML] Factor VIII/protein C ratio independently predicts liver-related events but does not indicate a hypercoagulable state in ACLD

B Scheiner, L Balcar, RJ Nussbaumer, J Weinzierl… - Journal of …, 2022 - Elsevier
Background & Aims It has been suggested that the ratio of procoagulant factor VIII to
anticoagulant protein C (FVIII/PC) reflects the hemostatic equilibrium. Moreover, FVIII/PC …

[HTML][HTML] Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis and adverse liver outcomes: results from a multi-ethnic Asian cohort

YW Ting, ASY Kong, SM Zain, WK Chan… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Methods Consecutive biopsy-proven NAFLD patients and controls without fatty liver were
recruited for this study between 2009 and 2014. Genotyping for HSD17B13 variants was …

Are we ready for genetic testing in metabolic dysfunction‐associated steatotic liver disease?

A Tulone, G Pennisi, C Ciccioli… - United European …, 2024 - Wiley Online Library
Metabolic dysfunction‐associated steatotic liver disease (MASLD), with its steadily
increasing prevalence, represents now a major problem in public health. A proper referral …

[HTML][HTML] Alpha-1 antitrypsin Pi∗ Z allele is an independent risk factor for liver transplantation and death in patients with advanced chronic liver disease

L Balcar, B Scheiner, M Urheu, P Weinberger… - JHEP Reports, 2022 - Elsevier
Background & Aims Alpha-1 antitrypsin (AAT) deficiency causes/predisposes individuals to
advanced chronic liver disease (ACLD). However, the role of the SERPINA1 Pi∗ Z allele in …

Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease

R Paternostro, K Staufer, S Traussnigg… - Hepatology …, 2021 - Springer
Objective Several single-nucleotide polymorphisms have been identified to be
disadvantageous or protective in regard to disease severity in patients with non-alcoholic …

[HTML][HTML] The impact of transmembrane 6 superfamily 2 (TM6SF2) rs58542926 on liver-related events in patients with advanced chronic liver disease

L Balcar, B Scheiner, M Urheu, P Weinberger… - Digestive and Liver …, 2023 - Elsevier
Background & aims Genetic factors such as the transmembrane 6 superfamily 2 (TM6SF2)
rs58542926 single nucleotide variant (SNV) modulate the susceptibility for (advanced) …

Liver phenotypes in PCOS: analysis of exogenous and inherited risk factors for liver injury in two European cohorts

W Smyk, I Papapostoli, M Żorniak… - Liver …, 2023 - Wiley Online Library
Abstract Background & Aims Fatty liver disease (FLD) is common in women with polycystic
ovary syndrome (PCOS). Here, we use non‐invasive tests to quantify liver injury in women …

Integrated proteomics and bioinformatics to identify potential prognostic biomarkers in hepatocellular carcinoma

Q Zhang, Z Xiao, S Sun, K Wang, J Qian… - Cancer Management …, 2021 - Taylor & Francis
Background Liver hepatocellular carcinoma (HCC) is the third most common cause of death
by cancer and has a high mortality world-widely. Approximately 75–85% of primary liver …

Effect of donor HSD17B13 genotype on patient survival after liver transplant: a retrospective cohort study

J Kozlitina, NM Cohen, D Sturtevant, JC Cohen… - …, 2024 - thelancet.com
Background Several genetic variants are associated with chronic liver disease. The role of
these variants in outcomes after liver transplantation (LT) is uncertain. The aim of this study …

Genetic susceptibility to chronic liver disease in individuals from Pakistan

AM Raja, E Ciociola, IN Ahmad, FS Dar… - International Journal of …, 2020 - mdpi.com
Chronic liver disease, with viral or non-viral etiology, is endemic in many countries and is a
growing burden in Asia. Among the Asian countries, Pakistan has the highest prevalence of …