The diameter of resistance arteries has a profound effect on the distribution of microvascular
blood flow and the control of systemic blood pressure. Here, we review mechanisms that …

Myogenic constriction is a vasoconstriction of blood vessels to increases in perfusion
pressure. In renal preglomerular vasculature, it is an established mechanism of renal blood …

Cold-induced vasoconstriction in cutaneous blood vessels is mediated in part by increased
activity of vascular smooth muscle α2-adrenoceptors (VSM α2-ARs). In mouse cutaneous …

Barrier dysfunction of pulmonary endothelial monolayer is associated with dramatic
cytoskeletal reorganization, activation of actomyosin contractility, and gap formation. The …

Endothelial cell (EC) permeability is precisely controlled by cytoskeletal elements [actin
filaments, microtubules (MT), intermediate filaments] and cell contact protein complexes …

Arterioles exposed to norepinephrine (NE) for 4 h exhibit incomplete relaxation on removal
of the agonist. We hypothesized that this is due to a mechanoadaptation process associated …

In isolated resistance arterioles with spontaneous tone, ligation of α4β1-and α5β1-integrins
induces vasoconstriction whereas ligation of αvβ3-integrin induces vasodilation. However …

Maintenance of endothelial cell tube integrity is dependent on an intact cytoskeleton. We
present data indicating that rapid collapse of endothelial tubular networks in vitro occurs in a …

Transforming growth factor‐β1 (TGF‐β1) is a cytokine critically involved in acute lung injury
and endothelial cell (EC) barrier dysfunction. We have studied TGF‐β1‐mediated signaling …

Smooth muscle (SM) exhibits a highly organized structural hierarchy that extends over
multiple spatial scales to perform a wide range of functions at the cellular, tissue, and organ …