Role of the serrated pathway in colorectal cancer pathogenesis
B Leggett, V Whitehall - Gastroenterology, 2010 - Elsevier
The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …
Melanoma: from mutations to medicine
H Tsao, L Chin, LA Garraway… - Genes & …, 2012 - genesdev.cshlp.org
Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
DJ Weisenberger, KD Siegmund, M Campan… - Nature …, 2006 - nature.com
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …
Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
JR Jass - Histopathology, 2007 - Wiley Online Library
Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …
multiple pathways. These pathways may be defined on the basis of two molecular …
Microsatellite instability: an update
H Yamamoto, K Imai - Archives of toxicology, 2015 - Springer
Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …
Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers
WS Samowitz, C Sweeney, J Herrick, H Albertsen… - Cancer research, 2005 - AACR
Abstract The BRAF V600E mutation has been associated with microsatellite instability and
the CpG island methylator phenotype (CIMP) in colon cancer. We evaluated a large …
the CpG island methylator phenotype (CIMP) in colon cancer. We evaluated a large …
Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma
Objective Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal
carcinomas, but their biology is incompletely understood. We performed a …
carcinomas, but their biology is incompletely understood. We performed a …
High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …
Malignant melanoma: genetics and therapeutics in the genomic era
L Chin, LA Garraway, DE Fisher - Genes & development, 2006 - genesdev.cshlp.org
Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics
K Imai, H Yamamoto - Carcinogenesis, 2008 - academic.oup.com
DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …