The process of sexual differentiation is central for reproduction of almost all metazoan, and
therefore, for maintenance of practically all multicellular organisms. In sex development, we …

Virilisation of the XX foetus is the result of androgen excess, resulting most frequently from
congenital adrenal hyperplasia in individuals with typical ovarian differentiation. In rare …

Androgens and anti-Müllerian hormone (AMH), secreted by the foetal testis, are responsible
for the development of male reproductive organs and the regression of female anlagen …

There have been considerable advances concerning understanding of the early and later
stages of ovarian development; a number of genes have been implicated and their …

PURPOSE: Little is known about long-term outcomes of conservative gonadal surgery in
true hermaphroditism. We present our experience with evaluation and treatment of a large …

The decision of the bi-potential gonad to develop into either a testis or ovary is determined
by the presence or absence of the Sex-determining Region gene on the Y chromosome …

Objectives: To describe the clinical features of children with ovotesticular disorder of sex
development (DSD) and to review cases of ovotesticular DSD in Japan. Methods: Medical …

Objective: To describe the clinical characteristics, biochemistry, histopathology, and long-
term outcomes in subjects with ovotesticular (OT) disorder of sex development (DSD). Study …

True hermaphroditism (TH) refers to individuals who have both unequivocal ovarian tissue
and testicular elements regardless of their karyotypes; whereas mixed gonadal dysgenesis …

Disorders of sex development (DSD) are rare disorders occurring when there is a
discordance between chromosomal, gonadal, or phenotypic sex. These occur in the …