Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Despite considerable research efforts, it is still not clear which mechanisms underlie
neuronal cell death in neurodegenerative diseases. During the last 20 years, multiple …

Diverse inflammatory conditions, from infections to autoimmune disease, are often
associated with cellular damage and death. Apoptotic cell death has evolved to minimize its …

Cognitive deficits are a common comorbidity with neurological disorders and normal aging.
Inflammation is associated with multiple diseases including classical neurodegenerative …

Gingival inflammation and alveolar bone loss are characteristic manifestations of
periodontitis. Interleukin (IL)-1β, the maturation of which is mainly regulated by NOD-like …

Emerging evidence shows that disrupted gut microbiota-bile acid (BA) axis is critically
involved in the development of neurodegenerative diseases. However, the alterations in …

Background Recent studies have revealed the link between immune activation and
neurodegenerative diseases. Methods By employing meta-analysis, we estimated the …

Background Mounting evidence links glucose intolerance and diabetes as aspects of
metabolic dysregulation that are associated with an increased risk of developing dementia …

Neurodegenerative diseases are characterized by extensive loss of function or death of
brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging …

Parthanatos is a cell death signaling pathway that has emerged as a compelling target for
pharmaceutical intervention. It plays a pivotal role in the neuron loss and neuroinflammation …