Microsatellite instability testing and its role in the management of colorectal cancer
H Kawakami, A Zaanan, FA Sinicrope - Current treatment options in …, 2015 - Springer
Opinion statement TNM stage remains the key determinant of patient prognosis after
surgical resection of colorectal cancer (CRC), and informs treatment decisions. However …
surgical resection of colorectal cancer (CRC), and informs treatment decisions. However …
Microsatellite instability in colorectal cancer
Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
HT Lynch, PM Lynch, SJ Lanspa, CL Snyder… - Clinical …, 2009 - Wiley Online Library
More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
[HTML][HTML] Endonucleolytic function of MutLα in human mismatch repair
FA Kadyrov, L Dzantiev, N Constantin, P Modrich - cell, 2006 - cell.com
Half of hereditary nonpolyposis colon cancer kindreds harbor mutations that inactivate
MutLα (MLH1• PMS2 heterodimer). MutLα is required for mismatch repair, but its function in …
MutLα (MLH1• PMS2 heterodimer). MutLα is required for mismatch repair, but its function in …
Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting
W Hankey, WL Frankel, J Groden - Cancer and Metastasis Reviews, 2018 - Springer
The acquisition of biallelic mutations in the APC gene is a rate-limiting step in the
development of most colorectal cancers and occurs in the earliest lesions. APC encodes a …
development of most colorectal cancers and occurs in the earliest lesions. APC encodes a …
[HTML][HTML] Mechanisms in eukaryotic mismatch repair
P Modrich - Journal of Biological Chemistry, 2006 - ASBMB
Inactivation of the human mismatch repair system confers a large increase in spontaneous
mutability and a strong predisposition to tumor development. Mismatch repair provides …
mutability and a strong predisposition to tumor development. Mismatch repair provides …
[HTML][HTML] Update on Lynch syndrome genomics
P Peltomäki - Familial cancer, 2016 - Springer
Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6,
and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of …
and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of …
Colorectal serrated adenocarcinoma
MJ Mäkinen - Histopathology, 2007 - Wiley Online Library
Colorectal cancer (CRC) ranks among the three most common cancers in terms of both
cancer incidence and cancer‐related deaths in most Western countries. Serrated …
cancer incidence and cancer‐related deaths in most Western countries. Serrated …
[HTML][HTML] Lynch syndrome genetics and clinical implications
P Peltomäki, M Nyström, JP Mecklin, TT Seppälä - Gastroenterology, 2023 - Elsevier
Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
Microsatellite instability and colorectal cancer
KB Geiersbach, WS Samowitz - Archives of pathology & …, 2011 - meridian.allenpress.com
Context.—About 15% of colorectal cancers are characterized by genomic microsatellite
instability, and of these, about 1 in 5 (2%–4% overall) are due to Lynch syndrome, a …
instability, and of these, about 1 in 5 (2%–4% overall) are due to Lynch syndrome, a …