Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

The first gene therapy clinical trials were initiated more than two decades ago. In the early
days, gene therapy shared the fate of many experimental medicine approaches and was …

The life span of patients with primary and secondary immunodeficiency is increasing due to
recent improvements in therapeutic strategies. While the incidence of primary …

Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) have TIR intracellular
domains that engage two main signaling pathways, via the TIR-containing adaptors MyD88 …

Complement deficiencies comprise between 1 and 10% of all primary immunodeficiencies
(PIDs) according to national and supranational registries. They are still considered rare and …

Primary immunodeficiencies are congenital disorders caused by defects in different
elements of the immune system. Affected patients usually present clinically with recurrent …

Primary B-cell immunodeficiencies refer to diseases resulting from impaired antibody
production due to either molecular defects intrinsic to B-cells or a failure of interaction …

Mammals coexist with an extremely dense microbiota in the lower intestine. Despite the
constant challenge of small numbers of microbes penetrating the intestinal surface …

The Textbook of Interdisciplinary Pediatric Palliative Care, by Drs. Joanne Wolfe, Pamela
Hinds, and Barbara Sourkes, aims to inform interdisciplinary teams about palliative care of …

Immunity is not simply the product of a series of discrete linear signalling pathways; rather it
is comprised of a complex set of integrated responses arising from a dynamic network of …