Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics
JJF Verhoef, JF Carpenter, TJ Anchordoquy… - Drug discovery today, 2014 - Elsevier
Highlights•PEGylated nanocarriers are linked to the accelerated blood clearance (ABC)
phenomenon.•The ABC is induced by anti-PEG antibodies and/or complement …
phenomenon.•The ABC is induced by anti-PEG antibodies and/or complement …
Chronic hyperuricemia, uric acid deposit and cardiovascular risk
D Grassi, L Ferri, G Desideri, P Di Giosia… - Current …, 2013 - ingentaconnect.com
Hyperuricemia is commonly associated with traditional risk factors such as dysglicemia,
dyslipidemia, central obesity and abnormal blood pressure, ie the metabolic syndrome …
dyslipidemia, central obesity and abnormal blood pressure, ie the metabolic syndrome …
Epidemiology of gout and hyperuricaemia in Italy during the years 2005–2009: a nationwide population-based study
Objective To assess the epidemiology of gout and hyperuricaemia in the Italian general
population during the years 2005–2009. Methods Using the Italian primary care database …
population during the years 2005–2009. Methods Using the Italian primary care database …
Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future
AN Ilinskaya, MA Dobrovolskaia - Toxicology and applied pharmacology, 2016 - Elsevier
Nanoparticle immunogenicity and antigenicity have been under investigation for many
years. During the past decade, significant progress has been made in understanding what …
years. During the past decade, significant progress has been made in understanding what …
Serum uric acid and the risk of incident and recurrent gout: a systematic review
A Shiozawa, SM Szabo, A Bolzani, A Cheung… - The Journal of …, 2017 - jrheum.org
Objective. Lowering serum uric acid (SUA) levels can essentially cure gout; however, this is
not widely practiced. To summarize epidemiologic evidence related to this causal link, we …
not widely practiced. To summarize epidemiologic evidence related to this causal link, we …
Gout: Rapid evidence review
KT Clebak, A Morrison, JR Croad - American family physician, 2020 - aafp.org
Gout is caused by monosodium urate crystal deposition in joints and tissues. Risk factors
include male sex; obesity; hypertension; alcohol intake; diuretic use; a diet rich in meat and …
include male sex; obesity; hypertension; alcohol intake; diuretic use; a diet rich in meat and …
Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)
F Liu, GL Du, N Song, YT Ma, XM Li, XM Gao… - Lipids in Health and …, 2020 - Springer
Background Hyperuricemia predisposes to gout, which may result in tophi, kidney stones, or
urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been …
urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been …
Future prospects of antibacterial metal nanoparticles as enzyme inhibitor
KBA Ahmed, T Raman, A Veerappan - Materials Science and Engineering …, 2016 - Elsevier
Nanoparticles are being widely used as antibacterial agents with metal nanoparticles
emerging as the most efficient antibacterial agents. There have been many studies which …
emerging as the most efficient antibacterial agents. There have been many studies which …
Update on importance of diet in gout
RN Beyl Jr, L Hughes, S Morgan - The American journal of medicine, 2016 - Elsevier
Gout is an inflammatory arthritis caused by deposition of monosodium urate crystals within
synovial joints. Although it is most well-known for its arthritis, gout has an intimate …
synovial joints. Although it is most well-known for its arthritis, gout has an intimate …
Crystal‐induced neutrophil activation
O Popa‐Nita, PH Naccache - Immunology and cell biology, 2010 - Wiley Online Library
Monosodium urate (MSU) crystals are among the most potent pro‐inflammatory stimuli and
an innate immune inflammatory response to the crystal surface is intimately involved in the …
an innate immune inflammatory response to the crystal surface is intimately involved in the …