Highlights•PEGylated nanocarriers are linked to the accelerated blood clearance (ABC)
phenomenon.•The ABC is induced by anti-PEG antibodies and/or complement …

Hyperuricemia is commonly associated with traditional risk factors such as dysglicemia,
dyslipidemia, central obesity and abnormal blood pressure, ie the metabolic syndrome …

Objective To assess the epidemiology of gout and hyperuricaemia in the Italian general
population during the years 2005–2009. Methods Using the Italian primary care database …

Nanoparticle immunogenicity and antigenicity have been under investigation for many
years. During the past decade, significant progress has been made in understanding what …

Objective. Lowering serum uric acid (SUA) levels can essentially cure gout; however, this is
not widely practiced. To summarize epidemiologic evidence related to this causal link, we …

Gout is caused by monosodium urate crystal deposition in joints and tissues. Risk factors
include male sex; obesity; hypertension; alcohol intake; diuretic use; a diet rich in meat and …

Background Hyperuricemia predisposes to gout, which may result in tophi, kidney stones, or
urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been …

Nanoparticles are being widely used as antibacterial agents with metal nanoparticles
emerging as the most efficient antibacterial agents. There have been many studies which …

Gout is an inflammatory arthritis caused by deposition of monosodium urate crystals within
synovial joints. Although it is most well-known for its arthritis, gout has an intimate …

Monosodium urate (MSU) crystals are among the most potent pro‐inflammatory stimuli and
an innate immune inflammatory response to the crystal surface is intimately involved in the …