The format of the original Hamilton Rating Scale for Depression (HAM-D) was unstructured:
only general instructions were provided for rating individual items. Over the years, a number …

Background Medication-induced salivary gland dysfunction (MISGD), xerostomia (sensation
of oral dryness), and subjective sialorrhea cause significant morbidity and impair quality of …

Context Antidepressant medications represent the best established treatment for major
depressive disorder, but there is little evidence that they have a specific pharmacological …

Background: Serotonin-noradrenaline reuptake inhibitors (SNRI) are widely used in medical
practice. Their discontinuation has been associated with a wide range of symptoms. The aim …

Background Valid assessment of drug efficacy and safety requires an evidence base free of
reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval …

Background Major depressive disorders have a significant impact on children and
adolescents, including on educational and vocational outcomes, interpersonal relationships …

Individuals suffering from depressive disorders display a greater incidence of hypertension
compared with the general population, despite reports of the association between …

Sexual dysfunction is a common symptom of depression. Although decreased libido is most
often reported, difficulties with arousal, resulting in vaginal dryness in women and erectile …

Antidepressant–placebo response-differences (RDs) in controlled trials have been
declining, potentially confounding comparisons among older and newer drugs. For clinically …

Background: In a study aimed at identifying the items carrying information regarding the
global severity of depression, the 6-item Hamilton Depression Rating Scale (HAM-D6) was …