[HTML][HTML] Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

[HTML][HTML] History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

[HTML][HTML] DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

A review of the possible associations between ambient PM2. 5 exposures and the development of Alzheimer's disease

Y Shou, Y Huang, X Zhu, C Liu, Y Hu… - … and Environmental Safety, 2019 - Elsevier
PM2. 5 particles in air pollution have been widely considered associated with respiratory
and cardiovascular diseases. Recent studies have shown that PM2. 5 can also cause …

[HTML][HTML] Alzheimer's disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

AR Monteiro, DJ Barbosa, F Remião, R Silva - Biochemical Pharmacology, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …

[HTML][HTML] Epigenetics across the human lifespan

RR Kanherkar, N Bhatia-Dey, AB Csoka - Frontiers in cell and …, 2014 - frontiersin.org
Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Histone acetylation: molecular mnemonics on the chromatin

J Gräff, LH Tsai - Nature Reviews Neuroscience, 2013 - nature.com
Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

[HTML][HTML] Arizona study of aging and neurodegenerative disorders and brain and body donation program

TG Beach, CH Adler, LI Sue, G Serrano… - … : official journal of the …, 2015 - ncbi.nlm.nih.gov
Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …

Monoaminergic neuropathology in Alzheimer's disease

G Šimić, MB Leko, S Wray, CR Harrington… - Progress in …, 2017 - Elsevier
None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …