Stem cell self-renewal is tightly controlled by the concerted action of stem cell-intrinsic
factors and signals within the niche. Niche signals often function within a short range …

Integrins on both tumor cells and the supporting host stromal cells in bone (osteoclasts, new
blood vessels, inflammatory cells, platelets and bone marrow stromal cells) play key roles in …

It is well known that mast cells are derived from hematopoietic stem cells. However, in adult
hematopoiesis, a committed mast cell progenitor has not yet been identified in any species …

Homing of hematopoietic stem cells (HSCs) into hematopoietic organs is a prerequisite for
the establishment of hematopoiesis during embryogenesis and after bone marrow …

We have explored the functional implications of inducible α4 integrin deletion during adult
hematopoiesis by generating a conditional-knockout mouse model, and we show that α4 …

Blood cell production originates from a rare population of multipotent, self-renewing stem
cells. A genome-wide gene expression analysis was performed in order to define regulatory …

The specific retention of intravenously administered hemopoietic cells within bone marrow is
a complex multistep process. Despite recent insights, the molecular mechanics governing …

New insights into the molecular biology of childhood leukemias have stimulated numerous
advances in diagnostic methods, strategies for risk assessment and the development of …

The involvement of the transcription factor c-Myb in promoting the proliferation and inhibition
of erythroid cell differentiation has been established in leukemia cell models. The anemia …

Transmissible spongiform encephalopathies (TSE) are a group of invariably fatal
neurodegenerative diseases and include scrapie in sheep, bovine spongiform …