The myelodysplastic syndromes (MDS) constitute a challenge for the biologist as well as for
the treating physician. In Section I, Dr. Willman reviews the current classifications and …

Integrin αIIb is a cell adhesion molecule expressed in association with β3 by cells of the
megakaryocytic lineage, from committed progenitors to platelets. While it is clear that …

α4β7 integrin is a cell adhesion receptor that is crucial for the migration of hematopoietic
progenitors and mature effector cells in the periphery, but its role in adult hematopoiesis is …

By controlling cell adhesion to the extracellular matrix, integrin receptors regulate processes
as diverse as cell migration, proliferation, differentiation, apoptosis, and synaptic stability …

Gene expression profiling relies on mRNA extraction from defined cell systems, which in the
case of pathological processes necessarily results in the use of small quantities of tissues …

An in vitro system has been established to study the migration of human melanoma cells
through a monolayer of endothelial cells. Endothelial cells were cultured to confluence on …

Abstract Context.—Myelodysplastic syndromes (MDSs) are clonal stem cell diseases
characterized by ineffective hematopoiesis, multilineage dysplasia, and peripheral …

Vinculin is a highly conserved actin-binding protein that is localized in integrin-mediated
focal adhesion complexes. Although critical roles have been proposed for integrins in …

OBJECTIVE: Recruitment of effector cell subsets to inflammatory lung, together with airway
resident cells responsive to secreted products, play pivotal roles in developing and …

OBJECTIVE: Hematopoietic progenitors generated by ex vivo expansion “home” less
efficiently to the bone marrow (BM) after intravenous transplantation than fresh cells. To …