Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Navigation through the bulk tumour, entry into the blood vasculature, survival in the
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …

Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance
to therapy and therefore understanding the underlying mechanisms is an urgent challenge …

Chemotherapy causes off‐target toxicity and is often ineffective against solid tumors.
Targeted and on‐demand release of chemotherapeutics remains a challenge. Here, cancer …

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic
behavior and induction mechanisms of CSCs are not well understood. Here, we employ …

Nanoparticulate drug delivery systems (Nano-DDSs) have emerged as possible solution to
the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Resistance to cancer therapy remains a major challenge in clinical oncology. Although the
initial treatment phase is often successful, eventual resistance, characterized by tumour …

Several lines of compelling pre-clinical evidence identify chemotherapy as a potentially
double-edged sword: therapeutic efficacy on the primary tumor may in fact be …

Local acidification of stroma is proposed to favour pre-metastatic niche formation but the
mechanism of initiation is unclear. We investigated whether Human Melanoma-derived …