Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

The inappropriate regenerated fibrous cartilage and subchondral bone of the injured
chondral defect ultimately cause degeneration of the regenerated cartilage, which …

Magnetic resonance imaging (MRI) is a well-established imaging technique for structural
assessment of knee osteoarthritis (OA) particularly in a research context. Conventional MRI …

Background: Metabolic syndrome–associated osteoarthritis (MetS-OA) is a distinct
osteoarthritis phenotype defined by the coexistence of MetS or its individual components …

The use of mesenchymal stem cells constitutes a promising therapeutic approach, as it has
shown beneficial effects in different pathologies. Numerous in vitro, pre-clinical, and, to a …

This study aimed to investigate the additional effect of ovariectomy-induced osteoporosis
(OP) on the pathology of knee osteoarthritis (OA) in a rat meniscectomized model …

Background The aim of the study was to investigate the effect of platelet-rich plasma (PRP)
on subchondral bone marrow edema (BME) and the level of biomarkers in synovial fluid of …

Objectives: Synovitis plays an important role in knee osteoarthritis (KOA) pain. The activation
of the NOD-like receptor protein 3 (NLRP3) inflammasome in fibroblast-like synoviocytes …

Articular cartilage degeneration has been proved to cause a variety of joint diseases, among
which osteoarthritis is the most typical. Osteoarthritis is characterized by articular cartilage …

Subchondral bone lesions, as the crucial inducement for accelerating cartilage
degeneration, have been considered as the initiating factor and the potential therapeutic …