Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases

D Paramanick, VD Singh, VK Singh - Journal of Controlled Release, 2022 - Elsevier
Alzheimer's disease (AD) is a neurological condition characterised by cognitive and
behavioural dysfunction. The presence of the blood brain barrier (BBB), which prevents …

[HTML][HTML] Puerarin: a potential natural neuroprotective agent for neurological disorders

X Liu, R Huang, J Wan - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese
medicine. Accumulating evidence has indicated that puerarin demonstrates multiple …

Effects of puerarin‐loaded tetrahedral framework nucleic acids on osteonecrosis of the femoral head

Y Zhao, S Li, M Feng, M Zhang, Z Liu, Y Yao, T Zhang… - Small, 2023 - Wiley Online Library
Osteonecrosis of the femoral head (ONFH) is recognized as a common refractory orthopedic
disease that causes severe pain and poor quality of life in patients. Puerarin (Pue), a natural …

Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis

P Jiang, L Zhou, L Zhao, X Fei, Z Wang, T Liu… - …, 2024 - nature.com
Autism spectrum disorder (ASD) is a complicated, neurodevelopmental disorder
characterized by social deficits and stereotyped behaviors. Accumulating evidence suggests …

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

Q Wang, ZN Shen, SJ Zhang, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Neurological diseases impose a tremendous and increasing burden on global health, and
there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried …

[HTML][HTML] Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment

Y Zhang, H Zhang, F Zhao, Z Jiang, Y Cui, M Ou… - … Pharmaceutica Sinica B, 2023 - Elsevier
Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological
functional recovery after ischemic stroke. The development of new approaches to …

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway

Q Zhang, M Yao, J Qi, R Song, L Wang, J Li… - Frontiers in …, 2023 - frontiersin.org
Introduction: Puerarin (PUE) is a natural compound isolated from Puerariae Lobatae Radix,
which has a neuroprotective effect on IS. We explored the therapeutic effect and underlying …

Research progress on acupuncture treatment in central nervous system diseases based on NLRP3 inflammasome in animal models

HM Zhang, D Luo, R Chen, SH Wang… - Frontiers in …, 2023 - frontiersin.org
Central nervous system (CNS) disorders exhibit complex neurophysiological and
pathological mechanisms, which seriously affect the quality of life in patients. Acupuncture …

Neutrophil hitchhiking for nanoparticle delivery to the central nervous system

Q Liu, X Li, Y Wang, X Liu, Y Cao, H Zhang, X Mu… - Applied Materials …, 2024 - Elsevier
Neurological diseases are of widespread concern due to high disability and mortality.
Nanodrugs have been developed for the treatment of a wide range of neurological …

Unveiling the neuroprotective properties of isoflavones: current evidence, molecular mechanisms and future perspectives

G Gong, K Ganesan, Y Wan, Y Liu… - Critical Reviews in …, 2024 - Taylor & Francis
Neurodegenerative diseases encompass a wide range of debilitating and incurable brain
disorders characterized by the progressive deterioration of the nervous system's structure …