Cannabinoids have a long record of recreational and medical use and become increasingly
approved for pain therapy. This development is based on preclinical and human …

In a recent cluster analysis, it has been shown that patients with peripheral neuropathic pain
can be grouped into 3 sensory phenotypes based on quantitative sensory testing profiles …

Aim Despite an improved understanding of the molecular mechanisms of nociception,
existing analgesic drugs remain limited in terms of efficacy in chronic conditions, such as …

Pain is a complex and subjective experience that poses a number of measurement
challenges. While self-report by the patient is viewed as the gold standard of pain …

As an indirect approach to relate previously identified sensory phenotypes of patients
suffering from peripheral neuropathic pain to underlying mechanisms, we used a published …

Central sensitization is a driving mechanism in many chronic pain patients, and manifests as
hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated …

Introduction Resting state functional connectivity (FC) is widely used to assess functional
brain alterations in patients with chronic pain. However, reports of FC accompanying tonic …

Potent and selective antagonists of the voltage-gated sodium channel Na V 1.7 represent a
promising avenue for the development of new chronic pain therapies. We generated a small …

Human experimental pain models are widely used to study drug effects under controlled
conditions, but they require further optimization to better reflect clinical pain conditions. To …

Person-centered care places the whole patient at the center of the assessment and
treatment plan. This includes an appreciation of the biological, psychological, and social …