T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
T cell exhaustion
A Baessler, DAA Vignali - Annual Review of Immunology, 2024 - annualreviews.org
T cell responses must be balanced to ensure adequate protection against malignant
transformation and an array of pathogens while also limiting damage to healthy cells and …
transformation and an array of pathogens while also limiting damage to healthy cells and …
Hepatitis C virus infection
MP Manns, M Buti, ED Gane, JM Pawlotsky… - Nature reviews Disease …, 2017 - nature.com
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …
CD8 T cell exhaustion during chronic viral infection and cancer
LM McLane, MS Abdel-Hakeem… - Annual review of …, 2019 - annualreviews.org
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
T-cell exhaustion in chronic infections: reversing the state of exhaustion and reinvigorating optimal protective immune responses
T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
Epidemiology and immune pathogenesis of viral sepsis
GL Lin, JP McGinley, SB Drysdale… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection
Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic
infection, developmental relationships and mechanisms underlying their fate decisions …
infection, developmental relationships and mechanisms underlying their fate decisions …
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
T cell exhaustion is an induced state of dysfunction that arises in response to chronic
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy
Purpose: Programmed cell death ligand 1 (PD-L1) is a molecule expressed on antigen-
presenting cells that engages the PD-1 receptor on T cells and inhibits T-cell receptor …
presenting cells that engages the PD-1 receptor on T cells and inhibits T-cell receptor …
Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …