RAGE plays key role in diabetic retinopathy: a review

ZW Lu, B Fan, YZ Li, YX Zhang - BioMedical Engineering OnLine, 2023 - Springer
RAGE is a multiligand receptor for the immunoglobulin superfamily of cell surface molecules
and is expressed in Müller cells, vascular endothelial cells, nerve cells and RPE cells of the …

Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated‐M1 Macrophage Polarization‐Dependent Vascular Smooth Muscle …

Y Xing, S Pan, L Zhu, Q Cui, Z Tang… - … Medicine and Cellular …, 2022 - Wiley Online Library
Objective. The objective of this study was to investigate the involved mechanisms of
advanced glycation end product‐(AGE‐) exacerbated atherosclerosis (AS). Methods. Toll …

Thermal inkjet bioprinting triggers the activation of the VEGF pathway in human microvascular endothelial cells in vitro

LH Solis, Y Ayala, S Portillo, A Varela-Ramirez… - …, 2019 - iopscience.iop.org
One biofabrication process that has gained tremendous momentum in the field of tissue
engineering and regenerative medicine is cell-printing or most commonly bioprinting. We …

Piperine attenuates lithocholic acid-stimulated interleukin-8 by suppressing Src/EGFR and reactive oxygen species in human colorectal cancer cells

S Li, TT Nguyen, TT Ung, DK Sah, SY Park… - Antioxidants, 2022 - mdpi.com
Piperine, a natural alkaloidal pungent product present in pepper plants, possesses the
properties of anti-inflammatory and anti-metastasis. Lithocholic acid is a monohydroxy-5beta …

A Mechanistic exploratory study on the therapeutic efficacy of astragaloside IV against diabetic retinopathy revealed by network pharmacology

ZH Zhao, M Xu, C Fu, Y Huang, TH Wang… - Frontiers in …, 2022 - frontiersin.org
Purpose: Diabetic retinopathy (DR) is a serious complication of diabetes mellitus, which
nearly happens to all the diabetic sufferers. This study aims to identify the preliminary …

Advanced glycation end products induce immature angiogenesis in in vivo and ex vivo mouse models

L Chen, Y Cui, B Li, J Weng, W Wang… - American Journal …, 2020 - journals.physiology.org
Proliferative diabetic retinopathy (PDR) is a progressive disease predominantly involving
pathological angiogenesis and is characterized by the development of immature, fragile …

Role of resveratrol on indoxyl sulfate‐induced endothelial hyperpermeability via aryl hydrocarbon receptor (AHR)/Src‐dependent pathway

EG Assefa, Q Yan, SB Gezahegn… - Oxidative Medicine …, 2019 - Wiley Online Library
Resveratrol (RES), a dietary polyphenol compound, has been shown to possess health
benefits due to its anti‐inflammatory, antioxidative, and antiatherosclerosis properties …

Involvement of CircRNA expression profile in diabetic retinopathy and its potential diagnostic value

H He, J Zhang, W Gong, M Liu, H Liu, X Li, Y Wu… - Frontiers in …, 2022 - frontiersin.org
Background: Circular RNAs (circRNAs), a class of non-coding and undegradable RNAs,
play many pathological functions by acting as miRNA sponges, interacting with RNA-binding …

Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity

J Wei, X Lu, X Bao, C Zhang, J Li, C Ren, Z Zhu… - European Journal of …, 2023 - Elsevier
Disruption of blood-testis barrier (BTB) was a crucial pathological feature of diabetes
induced-testicular injury at early phase. Aucubin (AU), a main active component in …

Lipopolysaccharides induce a RAGE-mediated sensitization of sensory neurons and fluid hypersecretion in the upper airways

M Nair, S Jagadeeshan, G Katselis, X Luan… - Scientific reports, 2021 - nature.com
Thoracic dorsal root ganglia (tDRG) contribute to fluid secretion in the upper airways.
Inflammation potentiates DRG responses, but the mechanisms remain under investigation …