The need for new antifungal agents is undeniable. Current therapeutic choices for the
treatment of invasive fungal infections are limited to three classes of drugs. Most used …

Nosocomial infections caused by fungi have increased greatly in recent years, mainly due to
the rising number of immunocompromised patients. However, the available antifungal …

Imidazoles are one of the most promising and vigorously pursued areas of contemporary
antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively …

Fungal based diseases currently affect nearly a quarter of the population around the world,
which diseases are usually limited to superficial infections. Perversely, along with the …

Antimycotic chemosensitization and its mode of action are of growing interest. Currently, use
of antifungal agents in agriculture and medicine has a number of obstacles. Foremost of …

Introduction: Invasive fungal infections (IFI) have increased significantly over the past
decades. The mortality rate of IFI is alarming, and early and accurate diagnosis is difficult …

Antifungal drugs belong to few chemical groups and such low diversity limits the therapeutic
choices. The urgent need of innovative options has pushed researchers to search new …

Introduction: Superficial infections involving the skin and mucosa are the most common
fungal disease in humans. Fungi can also produce invasive infections (IFI), which are …

The increasing resistance of pathogenic fungi to antifungal compounds and the reduced
number of available drugs led to the search for therapeutic alternatives among natural …

Background The currently available antifungal drugs suffer from toxicity, greatest potential
drug interactions with other drugs, insufficient pharmacokinetics properties, and …