Molecular physiology of bile acid signaling in health, disease, and aging
A Perino, H Demagny… - Physiological …, 2021 - journals.physiology.org
Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …
The human ATP‐binding cassette (ABC) transporter superfamily
M Dean, K Moitra, R Allikmets - Human mutation, 2022 - Wiley Online Library
The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that
efflux various substrates across extra‐and intracellular membranes. Mutations in ABC genes …
efflux various substrates across extra‐and intracellular membranes. Mutations in ABC genes …
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
Gallstones
F Lammert, K Gurusamy, CW Ko, JF Miquel… - Nature reviews Disease …, 2016 - nature.com
Gallstones grow inside the gallbladder or biliary tract. These stones can be asymptomatic or
symptomatic; only gallstones with symptoms or complications are defined as gallstone …
symptomatic; only gallstones with symptoms or complications are defined as gallstone …
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Alcohol misuse is the leading cause of cirrhosis and the second most common indication for
liver transplantation in the Western world,,. We performed a genome-wide association study …
liver transplantation in the Western world,,. We performed a genome-wide association study …
Pleiotropic roles of bile acids in metabolism
TQ de Aguiar Vallim, EJ Tarling, PA Edwards - Cell metabolism, 2013 - cell.com
Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that …
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that …
[HTML][HTML] Epidemiology of gallbladder disease: cholelithiasis and cancer
LM Stinton, EA Shaffer - Gut and liver, 2012 - ncbi.nlm.nih.gov
Diseases of the gallbladder are common and costly. The best epidemiological screening
method to accurately determine point prevalence of gallstone disease is ultrasonography …
method to accurately determine point prevalence of gallstone disease is ultrasonography …
An update on the pathogenesis of cholesterol gallstone disease
A Di Ciaula, DQH Wang… - Current opinion in …, 2018 - journals.lww.com
An update on the pathogenesis of cholesterol gallstone disea... : Current Opinion in
Gastroenterology An update on the pathogenesis of cholesterol gallstone disease : Current …
Gastroenterology An update on the pathogenesis of cholesterol gallstone disease : Current …
Cohort profile: the study of health in Pomerania
H Völzke, D Alte, CO Schmidt, D Radke… - International journal …, 2011 - academic.oup.com
Although in the past century mortality in West Germany decreased similarly as in other
Western nations, these changes were less pronounced in East Germany. 1, 2 After German …
Western nations, these changes were less pronounced in East Germany. 1, 2 After German …
Human genetic variation and its contribution to complex traits
The last few years have seen extensive efforts to catalogue human genetic variation and
correlate it with phenotypic differences. Most common SNPs have now been assessed in …
correlate it with phenotypic differences. Most common SNPs have now been assessed in …