Abstract 30 years after the identification of WNTs, their signal transduction has become
increasingly complex, with the discovery of more than 15 receptors and co-receptors in …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

Wnts are secreted proteins that bind to cell surface receptors to activate downstream
signaling cascades. Normal Wnt signaling plays key roles in embryonic development and …

Wnts are evolutionarily conserved secreted signalling proteins that, in various
developmental contexts, spread from their site of synthesis to form a gradient and activate …

Wnt proteins are secreted glycoproteins that regulate multiple processes crucial to the
development and tissue homeostasis of multicellular organisms, including tissue patterning …

Of fundamental interest to biologists is how organs achieve a reproducible size during
development. Studies of the developing Drosophila wing have provided many key insights …

The Wnt signal transduction pathway has essential roles in the formation of the primary body
axis during development, cellular differentiation and tissue homeostasis. This animal …

The intestine acts as one of the interfaces between an organism and its external
environment. As the primary digestive organ, it is constantly exposed to a multitude of …

Changes in gene expression during animal development are largely responsible for the
evolution of morphological diversity. However, the genetic and molecular mechanisms …

In the era of functional genomics, the role of transcription factor (TF)–DNA binding affinity is
of increasing interest: for example, it has recently been proposed that low-affinity genomic …