Cholestatic liver diseases are caused by a range of hepatobiliary insults and involve
complex interactions among environmental and genetic factors. Little is known about the …

The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and
transintestinal cholesterol excretion. Inactivating mutations on either the ABCG5 or ABCG8 …

Familial hypercholesterolaemia (FH) is characterized by increased circulating low-density
lipoprotein (LDL) cholesterol leading to premature atherosclerosis and coronary heart …

Intestinal cholesterol absorption varies widely between individuals, which may translate into
differences in responsiveness to cholesterol-lowering drugs or diets. Therefore …

Materials and methods From 1986 to 2012, 75 patients were found to have gallbladder
cancer during the study of 2942 patients affected by biliary tract diseases; 34 of these …

The presence of gallstone disease (GSD) was reported to be positively associated with
diabetes risk. Whether the association is causal remains unclear. We aim to examine the …

Abstract Latin Americans and Chilean Amerindians have the highest prevalence of gallstone
disease (GSD) and gallbladder cancer (GBC) in the world. A handful of loci have been …

Gallstone disease (GSD) is one of the most common biliary tract disorders worldwide. The
prevalence, however, varies from 5.9–21.9% in Western society to 3.1–10.7% in Asia. Most …

The heterodimer of ATP-binding cassette transporter ABCG5 and ABCG8 mediates the
excretion of sterols from liver and intestine, playing a critical role in cholesterol homeostasis …

Background Gallstone disease is associated with p. D19H of ABCG8 as well as alterations
of cholesterol and bile acid metabolism. However, molecular mechanisms have not been …